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First enable the Anti-spam Functionality:

1. Log on to the Hub Transport Server.
2. Go to “Start” -> “Programs” -> “Microsoft Exchange Server 2007”.
3. Open “Exchange Management Shell”.
4. Write “Install-AntispamAgents.ps1” and press on the “Enter” key.
5. Restart “Microsoft Exchange Transport” service.
6. Go to “Start” -> “Programs” -> “Microsoft Exchange Server 2007”.
7. Open “Exchange Management Console”.
8. Navigate to “Microsoft Exchange” -> “Organization Configuration” > “Hub Transport”.
9. A new tab, named “Anti-Spam” should appear.

Now configure automatic updates:

• To use the Exchange Management Console to enable anti-spam updates
  1. In the Exchange Management Console, click Edge Transport.
  2. Select the server on which the Exchange Anti-spam Update service is to be configured.
  3. In the Action pane, click Enable Anti-spam Updates.
• To use the Exchange Management Shell to enable anti-spam updates
  • To enable anti-spam Automatic Updates if the destination computer is already opted in to Microsoft Update, run the following command:

    Enable-AntispamUpdates -Identity SERVER01 -IPReputationUpdatesEnabled $True -UpdateMode Automatic -SpamSignatureUpdatesEnabled $True

  • To enable anti-spam Automatic Updates and opt in to Microsoft Update, run the following command:

    Enable-AntispamUpdates -Identity SERVER01 -IPReputationUpdatesEnabled $True -MicrosoftUpdate RequestedNotifyDownload -UpdateMode Automatic -SpamSignatureUpdatesEnabled $True

Sources:
How to install Microsoft Anti Spam Agents on Exchange 2007
How to Enable Anti-Spam Functionality on a Hub Transport Server
How to Configure Anti-Spam Automatic Updates